HPV comprises a family of over 200 genotypes, which can be loosely categorized based on oncogenicity into low risk (LR) and high-risk (HR) genotypes. LR genotypes, such as 6 and 11, preferentially infect cutaneous sites to cause skin warts and condyloma acuminata. HR genotypes, such as 16, 18, 31, 33, 45, 52 and 58, among others, preferentially infect mucosal sites and are associated with the development of certain vaginal, vulvar, cervical, penile, anal and oropharyngeal cancers.
A 78-year-old man presented to our hospital with a 1-year history of abdominal distension and constipation. Except for hypertension, he had no documented medical history. Physical examination was unremarkable. Laboratory examination confirmed no abnormality. Although no clues for abdominal distension were found, esophagogastroduodenoscopy demonstrated a large pedunculated duodenal mass with surface erosions. It was removed successfully with nylon loop
followed by snare resection. Pathological examination revealed massive Brunner gland proliferation and an abnormal architecture, which was consistent with the Brunner gland adenoma. Helicobacter pylori testing was negative.
It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science. The tried-and-true mode of discovery in 20th century medical therapeutics falls along this line: the beneficial effect of a substance is observed empirically during random testing or, conversely, new compounds are synthesized based on some existing pharmacologic principle; the substance undergoes testing in animals and, if no undesirable consequences ensue, clinical studies in humans are conducted.
Antibiotic drugs are the most frequently prescribed medications among hospitalized patients for life-saving purposes, mainly in immunocompromised patient, like in patient with end stage renal disease on hemodialysis (HD) or those who had documented bacterial infection. Antibiotics disposition and their pharmacokinetics and pharmacodynamics properties are affected in hemodialysis patient which increases the number of antibiotics dosing errors. Several epidemiological studies found that the majority of medication error related to antibiotics occurred during the prescribing phase (30.8%). However, there is missing data about the prevalence of errors in antibiotics dosing in HD patients.
We report the case of 69 years old female with a history of uncontrolled type 2 diabetes, who presented refractory and chronic right-sided purulent otorrhea with temporal headaches for 6 months, treated with no improvement by multiple attempts of ambulatory empiric therapy. After the appearance of grade III facial palsy and painful swelling in the right periorbital and zygomatic areas, the patient consulted in our department where a CT scan showed massive cortical and trabecular destruction of the right petrous bone and the mastoid extended to the lateral orbital wall, the zygomatic arch and the greater sphenoid wing realising extensive osteomyelitis of the skull base and the lateral face. The treatment was started immediately based on intravenous broad-spectrum antibiotics. Despite aggressive long-term treatment, the patient passed away, underlying the increased SBO morbidity and mortality secondary to delayed diagnosis.
COVID-19 is a worldwide public health problem that has attracted much attention due to its clinical and para-clinical findings. In the western Asia, Qom was the first city to report COVID-19 cases on a large scale. We report gastrointestinal (GI) manifestations, as the only primary signs of COVID-19 infection have been reported. Data were obtained from patients, referred to GI clinics in Qom city, from February 25th to March 15th, 2020 who had refractory GI symptoms but there was no detection of digestive diseases after typical medical examinations. They were requested to do follow up tests, eventually the patients were tested for COVID-19. The presence of COVID-19 was confirmed based on the WHO guidelines.
The aim of this study was to assess, identify and have a better understanding of the importance of patient safety culture within the healthcare organization and to create insights on the impact of cultural management systems regarding patient safety. The research method of this study is an integrated literature of the patient safety culture and perspectives of healthcare workers, assessed using the Modified Stanford Instrument (MSI) and Manchester Patient Safety Framework (MaPSaF).
Everybody is born with the mammary gland. Mammary gland development occurs through various stages throughout embryonic, and stays dormant for males. Although it is uncommon, male also gets breast cancer, occasionally. Male breast cancer accounts for approximately 1% of all breast cancer cases, and it is increasing. When compared with other rare diseases, male breast cancer is understudied. Typically, male breast cancer is treated in the same way as female breast cancer. In this article, the various aspects and attributes of male breast cancer and its treatment methods are reviewed.
The appendix testis may be involved in the normal testicular descent and there are reports of decreased incidence of appendix testis in children with undescended testis. The aim of this study was to evaluate the incidence of appendix testis in children with undescended testis in comparison to the incidence in children with normally descended testis.
Outcome of most of the biliary and pancreatic malignancy is not good. Demography and involvement of different sites of these malignancies by endoscopic retrograde cholagiopancreatography (ERCP) are not widely studied in Bangladesh. We have studied ERCP based different biliary and pancreatic malignancy and their demographic characteristics.
We experienced a rare case of 9-months-old girl with an abdominal neuroblastoma that exhibited radiographic evidence of tumor extension into the mesenteric artery. Imaging studies were suggestive of neuroblastoma which also confirmed by the histologic analysis that show a diagnosis of neuroblastoma too. The patient never underwent initial chemotherapy for the treatment of neuroblastoma but experienced operation for tumor and resection was successfully achieved. This case and the treatment strategy are discussed in this paper.
The Gazette of Medical Sciences adhere strictly to the policies and guidelines recommended by The Committee on Publication Ethics (COPE) and International Committee of Medical Journal Editors (ICMJE). An article published in a peer-reviewed open access journal is a vital element in the development of a coherent and respected network of knowledge. It is a direct reflection of the quality of the work of the authors and the institutions that support them. It is therefore important to set and accept certain standards and guidelines for the editors who are responsible for scrutinizing the articles and allow the publication of only useful and relevant content. Read more..
The Gazette of Medical Sciences is a peer-reviewed international journal, publishing bi-monthly issues in Open Access mode. It is indexed / archived by the major international indexing systems. The journal is committed to meeting and upholding standards of ethical behavior at all stages of the publication process. We follow closely the industry associations that set standards and provide guidelines for best practices in order to meet these requirements. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles. Read more..
Vice President, Western University of Health Sciences, CA, USA
Psychiatrist and Psychotherapist, NHS
Department of Mental Health, Italy
Chief, Orthopaedic Department, General Hospital, Patras, Greece
Professor, Central Lisbon University Hospital, Portugal
Department of Abdominal Transplant Surgery & Hepato-Biliary Surgery
Augusta University, GA
Head of Oncology, Bnai Zion Medical Center, Haifa, Israel
Medical-Surgical Consultant, Physiological Research Laboratories/Medtronic Inc., Minneapolis, Minnesota, US
Distinguished Professor, Chia Nan University of Pharmacy and Science, Taiwan
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