To diagnose diseases during gestation period including renal stones, appendicitis, and pulmonary embolism in pregnant patients, computed tomography (CT) can be a golden standard. Due to CT examination, the fetus is prone to receiving a considerable dose which is the result of direct or scattered (external and internal scattered radiation) beams. The effects of ionization radiation on fetus include mutagenesis and carcinogenesis, therefore, it is essential to reduce fetus dose for pregnant patients who undergo CT examination during gestation period. This article aims to review approaches that are effective in reducing fetal dose in pregnant patients.
We appreciate the attention and interest in our manuscript. The letter raises a handful of issues that pertain not simply to our description of the previously unrecognized phenomenon of magnetic attraction/attachment but regarding the scientific method itself and the generation of new scientific knowledge. These issues must be carefully considered one by one.
I was fascinated by the study by Thorp et al. on the magnetic effects of Covid-19 vaccination – or rather the lack of the same . The paper’s title is in no way supported by the data. A static magnetic field is a force. The investigators did not do any tests for energy, and even their tests for magnetism were seriously flawed. They did not think to try a non-ferrous or non-metallic test article, so non-magnetic adhesive factors cannot be ruled out.
In recent months unexpected reports have surfaced claiming the presence of magnetic attraction in the shoulder regions of subjects who had recently received the COVID-19 vaccination. To determine if such claims are legitimate or spurious, a prospective observational study was performed utilizing standard neodymium magnets and non-magnetized paper clips in a rigorously standardized application protocol. Magnets and paper clips were applied over various regions of both deltoid muscles. The attraction score was calculated by adding one point for each pole of the magnet that attached to each arm over the deltoid muscle for a maximum score of 4. Likewise, three sizes of paper clips were tested with a maximum score of 6. The field score was calculated by adding the magnet score to the paper clip score for a maximum score of 10 points
Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer effect of an ethanol extract of MC fruit, Kuguacin-J (K-J), an isolated compound from the leaves of MC and cisplatin, either alone or combination on healthy MCF-10A mammary cells and compared with breast cancer MCF-7 and MDAMB-231 cell lines.
Interest in modulating the immune response beyond glucocorticoids has existed since the COVID-19 pandemic began. Recent trials have shown promising results with IL-6 inhibitors such as tocilizumab although similar data on Sarilumab is lacking. In this report, we analyze the current evidence on Sarilumab in hospitalized COVID-19 patients to evaluate its efficacy.
It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science. The tried-and-true mode of discovery in 20th century medical therapeutics falls along this line: the beneficial effect of a substance is observed empirically during random testing or, conversely, new compounds are synthesized based on some existing pharmacologic principle; the substance undergoes testing in animals and, if no undesirable consequences ensue, clinical studies in humans are conducted.
Chronic degenerative diseases like obesity, metabolic syndrome, diabetes, fatty liver, have gained high prevalence in the world, due to sedentarism, improper nutritional habits as well as alcohol and tobacco consumption. Studies have shown that regular consumption of breakfast leads to a wide range of benefits, especially for the liver. The liver is a key organ for metabolic homeostasis regulating and governing energy metabolism, mostly providing nutrients for reabsorption. Benefits of a nutrimental quality breakfast seem to help lower body mass index, prevent metabolic diseases, and overall improve quality of life. Unfortunately, these include either high cholesterol or high-sugar foods including cold cuts, bread, eggs, and sugary beverages. Also, much of the population’s work schedule relates to long hours and high-level of stress, therefore malnutrition, and inadequate eating schedules are common.
Multi-organ procurement was performed on a 48-year-old donor after the patient was declared brain dead. A standard approach was performed for two dissections of abdominal organs. During the cold phase of dissection, an additional left sided retro-aortic vein was identified. The second vein hadseparate opening to the inferior vena cava in addition to the normal positioned pre-aortic left renal vein. Both veins were divided close to the origin from the inferior vena cava. During the back table preparation, it was noticed that same volume of preservative fluid was identified to be draining from both veins. Both veins were isolated and anastomosed separately on the 61-year-old recipient. Patient was initiated on anti-platelet therapy and made successful recovery.
HPV comprises a family of over 200 genotypes, which can be loosely categorized based on oncogenicity into low risk (LR) and high-risk (HR) genotypes. LR genotypes, such as 6 and 11, preferentially infect cutaneous sites to cause skin warts and condyloma acuminata. HR genotypes, such as 16, 18, 31, 33, 45, 52 and 58, among others, preferentially infect mucosal sites and are associated with the development of certain vaginal, vulvar, cervical, penile, anal and oropharyngeal cancers.
A 78-year-old man presented to our hospital with a 1-year history of abdominal distension and constipation. Except for hypertension, he had no documented medical history. Physical examination was unremarkable. Laboratory examination confirmed no abnormality. Although no clues for abdominal distension were found, esophagogastroduodenoscopy demonstrated a large pedunculated duodenal mass with surface erosions. It was removed successfully with nylon loop
followed by snare resection. Pathological examination revealed massive Brunner gland proliferation and an abnormal architecture, which was consistent with the Brunner gland adenoma. Helicobacter pylori testing was negative.
Antibiotic drugs are the most frequently prescribed medications among hospitalized patients for life-saving purposes, mainly in immunocompromised patient, like in patient with end stage renal disease on hemodialysis (HD) or those who had documented bacterial infection. Antibiotics disposition and their pharmacokinetics and pharmacodynamics properties are affected in hemodialysis patient which increases the number of antibiotics dosing errors. Several epidemiological studies found that the majority of medication error related to antibiotics occurred during the prescribing phase (30.8%). However, there is missing data about the prevalence of errors in antibiotics dosing in HD patients.
We report the case of 69 years old female with a history of uncontrolled type 2 diabetes, who presented refractory and chronic right-sided purulent otorrhea with temporal headaches for 6 months, treated with no improvement by multiple attempts of ambulatory empiric therapy. After the appearance of grade III facial palsy and painful swelling in the right periorbital and zygomatic areas, the patient consulted in our department where a CT scan showed massive cortical and trabecular destruction of the right petrous bone and the mastoid extended to the lateral orbital wall, the zygomatic arch and the greater sphenoid wing realising extensive osteomyelitis of the skull base and the lateral face. The treatment was started immediately based on intravenous broad-spectrum antibiotics. Despite aggressive long-term treatment, the patient passed away, underlying the increased SBO morbidity and mortality secondary to delayed diagnosis.
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Vice President, Western University of Health Sciences, CA, USA
Psychiatrist and Psychotherapist, NHS
Department of Mental Health, Italy
Professor, Central Lisbon University Hospital, Portugal
Department of Abdominal Transplant Surgery & Hepato-Biliary Surgery
Augusta University, GA
Head of Oncology, Bnai Zion Medical Center, Haifa, Israel
Distinguished Professor, Chia Nan University of Pharmacy and Science, Taiwan