One hundred years of diet-heart research: Good science, junk science and honest mistakes
This perspective critically examines the historical development of diet–heart research and the interpretation of evidence concerning dietary fats, cholesterol and cardiovascular disease. The authors discuss early experimental studies, dietary recommendations, food-processing practices and the potential significance of cholesterol oxidation products and lipid oxidation products generated during heating and storage. They question aspects of conventional interpretations and emphasize the importance of experimental design, chemical analysis and scientific scrutiny. The article presents the authors' interpretations of a contested research field rather than a consensus clinical guideline.
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