Department of Pharmacology

Aims and Scope

Understanding how medicines interact with living systems is fundamental to safe and effective treatment. The Department of Pharmacology of The Gazette of Medical Sciences (The GMS) provides an international, peer-reviewed, open-access platform for investigations into the mechanisms, therapeutic actions, biological responses and adverse effects of drugs and other pharmacologically active substances. Its scope extends from molecular and cellular pharmacology to experimental, clinical and population-based studies. The Department particularly encourages research that establishes meaningful connections between pharmacological mechanisms, measurable drug effects and patient-relevant outcomes.

Mechanistic pharmacology is a central focus of the Department. Contributions may investigate receptor signaling, ion channels, transporters, enzymes, intracellular pathways, drug targets, dose–response relationships, receptor occupancy, agonism, antagonism, tolerance and drug resistance. Experimental studies exploring cardiovascular, neurological, endocrine, respiratory, renal, gastrointestinal, immune and cancer pharmacology are welcomed. The Department also considers research on natural compounds, biological therapeutics and emerging pharmacological agents, provided that conclusions are supported by appropriate experimental or clinical evidence.

The Department places particular importance on pharmacokinetics, pharmacodynamics and their integration in therapeutic decision-making. Relevant topics include drug absorption, distribution, metabolism, elimination, bioavailability, clearance, exposure–response relationships, drug–drug interactions, pharmacogenomics, population pharmacokinetics and pharmacometrics. Studies addressing therapeutic drug monitoring, individualized dosing, special populations, organ impairment and variability in treatment response are encouraged. Mathematical, computational and model-informed approaches are welcomed when they improve understanding of drug behavior or support evidence-based dosing strategies.

Clinical pharmacology and pharmacotherapeutics form another major area of interest. The Department welcomes investigations into drug efficacy, comparative effectiveness, medication safety, adverse drug reactions, pharmacovigilance, medication errors, polypharmacy and drug-related clinical outcomes. Research may address rational prescribing, drug utilization, real-world evidence, clinical trial pharmacology, therapeutic risk–benefit assessment and treatment optimization. Particular consideration is given to studies of vulnerable populations, including children, older adults, pregnant patients and individuals with multiple medical conditions.

The Department also supports translational and reverse translational pharmacology, connecting laboratory discoveries with clinical observations and using clinical evidence to refine mechanistic hypotheses. Research involving experimental pharmacology, toxicology, systems pharmacology, computational pharmacology, precision therapeutics and pharmacological approaches to unmet medical needs is encouraged. Original research, systematic and narrative reviews, mini-reviews, short communications, case-based pharmacological reports, commentaries, editorials and scholarly perspectives are considered within scope. Scientific rigor, transparent reporting, ethical conduct and careful distinction between preclinical findings and established clinical benefits are essential editorial considerations.

Areas of Interest

• Pharmacokinetics
• Pharmacogenomics
• Pharmacometrics
• Drug Interactions
• Therapeutic Drug Monitoring
• Pharmacovigilance
• Pharmacodynamics
• Molecular Pharmacology
• Cellular Pharmacology
• Experimental Pharmacology
• Clinical Pharmacology
• Translational Pharmacology
• Reverse Translational Pharmacology
• Receptor Pharmacology
• Drug–Receptor Interactions
• Receptor Signaling Pathways
• Ion Channel Pharmacology
• Transporter Pharmacology
• Enzyme Inhibition and Modulation
• Drug Targets and Mechanisms
• Dose–Response Relationships
• Drug Absorption
• Drug Distribution
• Drug Metabolism
• Drug Elimination and Clearance
• Bioavailability
• Exposure–Response Modeling
• Population Pharmacokinetics
• PK/PD Modeling
• Model-Informed Drug Development
• Individualized Drug Dosing
• Precision Pharmacotherapy
• Pharmacogenetics
• Interindividual Drug Response
• Drug Resistance and Tolerance
• Adverse Drug Reactions
• Drug Safety Assessment
• Drug-Induced Organ Toxicity
• Drug–Drug Interactions
• Drug–Food Interactions
• Polypharmacy
• Medication Errors
• Medication Safety
• Rational Prescribing
• Clinical Pharmacotherapeutics
• Comparative Drug Effectiveness
• Drug Utilization Studies
• Real-World Pharmacological Evidence
• Clinical Trial Pharmacology
• Pediatric Pharmacology
• Geriatric Pharmacology
• Maternal and Fetal Pharmacology
• Cardiovascular Pharmacology
• Neuropharmacology
• Psychopharmacology
• Endocrine Pharmacology
• Respiratory Pharmacology
• Renal Pharmacology
• Gastrointestinal Pharmacology
• Immunopharmacology
• Inflammation Pharmacology
• Cancer Pharmacology
• Antimicrobial Pharmacology
• Antiviral Pharmacology
• Analgesic Pharmacology
• Anesthetic Pharmacology
• Perioperative Pharmacology
• Natural-Product Pharmacology
• Experimental Toxicology
• Nanoparticle Pharmacology
• Systems Pharmacology
• Computational Pharmacology
• Quantitative Systems Pharmacology
• Pharmacological Biomarkers
• Therapeutic Risk–Benefit Assessment
• Evidence-Based Pharmacotherapy

The Department encourages contributions that clarify drug mechanisms, strengthen therapeutic evidence or improve the safe use of medicines. Submissions undergo editorial assessment and peer review in accordance with The GMS publication and research integrity policies.