Advancing clinical and translational neuroscience, neurological research, and understanding of disorders affecting the brain, spinal cord and nervous system.
Disorders of the nervous system present some of the most complex challenges in medicine, affecting movement, sensation, cognition, behaviour, consciousness and essential physiological functions. Understanding these conditions requires an integrated examination of neural structure, molecular mechanisms, electrical activity, vascular function and the interaction between the nervous system and the wider body. The Department of Neurology of The Gazette of Medical Sciences (The GMS) provides a platform for clinical, experimental and translational investigations addressing neurological health and disease. Its scope extends from fundamental discoveries in neuroscience to diagnostic advances, therapeutic interventions and the long-term management of neurological disorders.
Clinical neurology forms a central component of the Department's scientific coverage. Research concerning epilepsy, stroke, dementia, Parkinson's disease, Alzheimer's disease, multiple sclerosis, peripheral neuropathies, neuromuscular disorders, headache syndromes, sleep-related neurological conditions and other disorders of the central and peripheral nervous systems is welcomed. Particular interest is given to studies that improve understanding of disease presentation, natural history, differential diagnosis, prognostic factors and treatment outcomes. Clinical trials, observational investigations, prospective and retrospective studies, case series and well-documented case reports may contribute valuable evidence, especially where they clarify uncommon presentations or important clinical decisions.
Advances in neuroscience increasingly connect neurological symptoms with processes occurring at cellular, molecular and systems levels. The Department therefore encompasses neuroanatomy, neurophysiology, neurochemistry, neurogenetics, neuroimmunology, neuroinflammation, neurodegeneration, neurodevelopment and the cellular biology of neural injury and repair. Investigations employing electrophysiology, neuroimaging, immunohistochemistry, molecular techniques, experimental disease models and computational approaches are encouraged when they contribute to understanding neurological mechanisms. Research examining protein aggregation, synaptic dysfunction, neuronal metabolism, neurovascular interactions and the biological foundations of cognition and behaviour also falls within the Department's remit.
The translation of neurological knowledge into improved patient care is an important priority. Contributions may evaluate pharmacological treatments, drug repurposing, neurorehabilitation, neuromodulation, neurostimulation, interventional neuroradiology, neurosurgical approaches and emerging therapeutic technologies. The Department also welcomes investigations involving artificial intelligence, deep learning, computational neuroscience, digital biomarkers, brain-computer interfaces and precision approaches to neurological diagnosis and treatment. Collaborative work involving neurologists, neurosurgeons, neuroscientists, rehabilitation specialists, radiologists, geneticists and biomedical engineers is particularly relevant when it addresses clinically meaningful neurological questions.
Neurological research must ultimately connect scientific discovery with reliable evidence and meaningful patient outcomes. The Department welcomes original research, systematic and narrative reviews, methodological studies, clinical investigations, case reports and carefully developed theoretical perspectives within the journal's applicable article categories. Manuscripts should present clearly defined objectives, appropriate study designs, transparent methods, ethically conducted investigations and interpretations supported by the available evidence. Where hypotheses depart from established neurological understanding, authors should distinguish proposed mechanisms from experimentally or clinically validated findings. Through critical scientific evaluation and peer review, the Department seeks to strengthen the exchange of neurological knowledge and encourage research that advances the understanding, prevention, diagnosis and treatment of nervous system disorders.
This paper investigates Drug Repurposing for Parkinson’s Disease with Deep Learning. The methodology used is Drug Discovery via Virtual Screening. Various existing drugs were screened and binding scores obtained to find potential efficacy that may inhibit Parkinson’s Disease. An end-to-end Drug Repurposing pipeline was built for the study.
View / Download Article ↗In this paper we explore the dynamic basis of epilepsy, the sacred disease, and show, surprisingly, that in all cases its manifest signs and symptoms correspond to the four-tier vertical framework – material, efficient, formal and final causes – advanced by Aristotle a half-century after the Hippocratic works surfaced. Specifically, impaired energy dynamics during the seizure state transiently disrupt the couplement between the material and formal causal layers of the body precipitating the behavioral alterations that define epilepsy.
View / Download Article ↗In this paper we examine 20th century conceptual developments regarding dementia and the NDs, from the first recognition of their clinical and pathological characteristics, through recognition of their molecular and cellular attributes and, ultimately, to recognition of their dynamic and vascular origins. We introduce a new energybased causal model of these disabling neurologic conditions that provides vital insights into their origins and necessary treatment. The term ‘causal’ implies that future treatment of these conditions necessarily entails recognition and correction of underlying energy deficits.
View / Download Article ↗The recent recognition of intravascular amyloid formation with deposition of insoluble microthrombi throughout the circulatory system in primary COVID-19 infection or following administration of mRNA vaccines is a pivotal discovery that alters conventional notions about the nature of the underlying pathologic process at play in SARS-CoV-2 infection.
View / Download Article ↗We report the case of 69 years old female with a history of uncontrolled type 2 diabetes, who presented refractory and chronic right-sided purulent otorrhea with temporal headaches for 6 months, treated with no improvement by multiple attempts of ambulatory empiric therapy.
View / Download Article ↗Pseudomeningoceles are rare complications of laminectomy surgery. Such clinical condition results from an inadvertent surgical dural rupture. We describe in the present study the report of a patient who developed iatrogenic pseudomeningocele in the lumbar region after performing a left laminectomy in L5 topography.
View / Download Article ↗Alzheimer’s disease (AD) is the most common degenerative brain disease in the aged population. By 2050, AD prevalence is expected to increase from 4.7 million (based on 2010 census) to 13.8 million people. It is characterized by the progressive decline of cognition and memory, as well as changes in behavior and personality.
View / Download Article ↗This simple method specifically stained ramified microglia in rat cerebral cortex, and the quality was quite comparable to that obtained by an indirect fluorescent antibody technique (IFAT) and an avidin biotin-peroxidase complex method (ABCM).
View / Download Article ↗Tuberous Sclerosis Complex or Bourneville’s disease is an autosomal dominant disease with high penetrance and variability characterized by multisystem involvement by benign lesions, originally defined by the classic triad of Vogt: sebaceous adenoma, epilepsy and mental retardation.
View / Download Article ↗This is a report to create awareness among clinicians on a very rare condition of thunderclap headache. A 51-year-old lady presented with recurrent thunderclap headaches over the preceding 3 days. In this report, the clinical presentation, investigation and management for Reversible Cerebral Vasoconstriction Syndrome (RCVS) including its outcome are described.
View / Download Article ↗Priapism as such is rare in spinal cord injury. It can be ischemic or non ischemic Priapism. The ischemic variety is painful and spontaneous while non ischemic is painless making diagnosis delayed. Penile gas gangrene in spinal cord injury is rare, but could be initiated in patients with ischemic Priapism as a triggering factor.
View / Download Article ↗Please direct any enquiry or submit papers to: info@thegms.co
