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Department-wise publication Updates

Dermatology

Managing pregnancy in a patient with Recessive Dystrophic Epidermolysis Bullosa: A case report

Epidermolysis Bullosa (EB) is a rare, heritable skin disease that encompasses several subtypes, which vary widely in presentation and prognosis. One subtype, Recessive Dystrophic Epidermolysis Bullosa (RDEB), is especially rare and debilitating. It occurs due to a mutation in the COL7A1 gene that encodes for type VII collagen leading to chronic, diffuse skin and mucosal blistering. Given the rarity of the disease, guidelines for treatment of pregnant patients with RDEB do not currently exist. This case describes the pregnancy course of a 21-year-old female with RDEB.

The relationship between age and skin healing

Proportion of elderly individuals in the population has increased, consequently, practitioners are often confronted to wound healing in elderly patients. The objective of this article is to approach skin aging and its consequences on skin healing, disorders of skin healing due to dermatoporosis and finally, specific comorbidities of the elderly that can cause wound healing perturbations. Considering these specificities, skin healing in the elderly is complicated and require a multidisciplinary management.

Pediatrics

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Acute Idiopathic Scrotal Edema: A 10-year period retrospective study

This article reports a case series of children diagnosed of Acute Idiopathic Scrotal Edema in a secondary referred hospital over a 10-year period, including the description of its clinical manifestations, management and evolution of this condition. A retrospective chart review was performed. It was found to include 11 patients, between 19 months and 12 years old, who presented scrotal edema and/or erythema with no self-explanatory trigger.

Orbital emphysema and blurred vision in a healthy 10-year-old girl

A 10-year-old girl is evaluated in the Emergency Department (ED) for acute pain, blurred vision and swelling of her left eye, which worsened when blowing her nose, after a contusion. She had hit her left eye with her knee while playing on a trampoline earlier that morning. The patient’s past history is unremarkable other than allergic rhinitis and sinusitis. 

Mental retardation, periventricular white matter hyperintensity on brain magnetic resonance imaging, retinitis pigmentosa, optic atrophy: A new genetic syndrome

Leukodystrophy is a typical example of progressive cerebral periventricular white matter brain disorders. The occurrence of leukodystrophic white matter on magnetic resonance imaging in with children non-progressive poorly defined non-specific disorders has been recognized.

Hepatology

Association of haematological and biochemical parameters, ultrasonographic and upper GI endoscopic findings with sero prevalence of HBV and HCV among chronic liver disease patients in a tertiary care hospital

Now-a-days chronic liver disease is one of the major health problems in the world. In developing countries, chronic liver disease due to hepatitis virus (like hepatitis B and hepatitis C virus) is increasing day by day. It is rapidly emerging as a major health problem. So, the present study was conducted to document the hepatitis B and hepatitis C virus in patient with chronic liver disease by an easy and simple marker like HBsAg, Anti HBc (total) and Anti HCV in a tertiary hospital.

Medical Genetics

The role of mutations on gene SLITRK1, in Tourette’s Syndrome

Tourette’s syndrome is a complex genetic disorder characterized by repetitive, sudden, or tic-like movements. Tics usually appear in childhood and their severity changes over time. In most cases, tics are less common in the last years of adolescence and adulthood. People with Tourette’s syndrome perform repetitive, involuntary movements known as tics. In addition, people with Tourette’s syndrome make sounds that are incomprehensible. Some tics involve only one muscle group, such as the occasional blinking or contact of the chin with the shoulder, or the shaking of the nostrils, which are usually the first
signs of Tourette’s syndrome. 

Bioinformatics

Bioinformatics analysis of myocardial immune progression

The immune infiltration and molecular mechanisms underlying septic cardiomyopathy (SC) have not been completely elucidated. This study aimed to identify key genes related to SC and elucidate the potential molecular mechanisms. The weighted correlation network analysis (WGCNA), linear models for microarray analysis (LIMMA), protein-protein interaction (PPI) network, CIBERSORT, Kyoto Encyclopedia of Genes and Genomes pathway (KEGG), and gene set enrichment analysis (GSEA) were applied to assess the key pathway and hub genes involved in SC.

Microbiology

Isolation, identification and biochemical profile of pathogenic and opportunistic bacteria from sore throat

Streptococcus pyogenes is the most common bacterial agent of sore throat. However, prescription of antibiotics due to clinical diagnosis only could disturb the microbiota and result in antibiotic resistant. 591 throat swabs samples were obtained from 308 participants. Swabs culture followed by isolation of all types of bacterial growth, which were subjected to morphological, microscopic and biochemical analysis. PCR confirmation performed for S. pyogenes isolates

Nephrology

Serum Soluble Interleukin 2 Receptor Alpha vs Urinary Parameters as a monitoring tool of treatment response of Lupus Nephritis and their relation to Lupus Nephritis Class on renal biopsy

Lupus Nephritis (LN) is one of the most common and serious manifestations in SLE patients that causes significant morbidity and mortality. Current conventional biomarkers for lupus nephritis like urine sediments, proteinuria, anti-dsDNA antibodies and C3 or C4 are sometimes mislead for prediction of treatment response. Recently IL-2 R alpha has shown to be a good marker to predict treatment response of lupus nephritis. 

A positive outcome with extremely severe metabolic acidosis: A case report

This is an entrancing case report of extremely severe metabolic acidosis occurred to a 46-year-old female who was admitted to intensive care medicine, Ninewells hospital. She presented with vomiting and collapsed with significant deranged metabolic acidosis. Despite carrying very guarded prognosis on admission, fortunately she survived following effective management from multidisciplinary team in the hospital. This case describes the metabolic acidosis in association with the mortality including the clinical presentation, management and the outcome. 

Microvita Sciences

The Hydrogen Atom as an Integrative Eigenstate of the Bifurcating Quantum Field

The present paper proposes an interpretation of quantum mechanics whereby the matter wave and its eigenstates are formed through an underlying, bifurcative self-interaction of the quantum field. Subsequently it will be shown that based on the latter the proton-to-electron mass ratio can accurately be calculated.

Orthopedics

Video Endoscopic Surgery in the Treatment of Lumbar Canal Stenosis: A systematic review

A Lumbar spinal stenosis is characterized by a central or transforaminal ways of compression which results in pain and compressive functional progressive loss. Studies show that the best form of treatment for this condition is a surgical decompression that has lately been associated with endoscopy video.

Pregabalin preoperative single dose for pain control after lombar videoendoscopic discectomy: A Prospective study

Twenty patients with lombar disc hernia and indication of surgical treatment were randomly allocated into two groups. The first group received 150 mg of pregabalin one hour before the anesthetic indication, the second group received conventional treatment without pregabalin. After the surgeries, the patient was asked to identify the intensity of his pain on a visual scale. The pain assessment occurred 24 hours and 7 days after the procedure.

Using intraoperative foraminoplasty in the prophylaxis of dysesthesia in transforaminal endoscopic discectomies of the lumbar spine

Postoperative nerve root injury with dysesthesia is the most frequent sequela following lumbar endoscopic transforaminal discectomy. At times, it may be accompanied by transient and rarely by permanent motor weakness. The authors hypothesized that direct compression of the exiting nerve root and its dorsal root ganglion (DRG) may play a role by manipulating the working cannula or endoscopic instruments.

Surgical site infections after orthopedic procedures in a tertiary hospital in Oman: Incidence, characteristics and risk factors

 

Surgical site infection (SSI) is a devastating complication of any surgery with negative impact on health care system worldwide. SSIs after orthopedic procedures have a wide range of effect on mortality and morbidity involving loss of implants and extension to bone and joint. This study aimed to determine the incidence of SSIs after different orthopedic procedures and their risk factors. Determining the characteristics of these SSIs and the common pathogens responsible for them were also aimed. 

Pharmacology

A clinical mini-review: Clinical use of Local anesthetics in cancer surgeries

The application of local anesthetics is frequently involved in anesthesia in the surgical treatment of various cancers. It is used in addition to or instead of general anesthesia as a way to provide control of sensation and pain to specific regions or parts of the patients’ bodies. They are thought to reduce the requirement for volatile anesthetics and opioids used in the surgery. This mini-review briefly summarized and commented on the frequent use of local anesthetics in cancer surgeries.

Anti-dyslipidemic effect of zinc oxide nanoparticles against cyclophosphamide induced dyslipidemia in male albino rats

Cyclophosphamide (CP) is used for the treatment of ovarian cancer, breast cancer, chronic lymphocytic leukemia, non-Hodgkin’s lymphoma, neuroblastoma, soft tissue sarcoma, rhabdomyosarcoma, and Wilms’ tumor. It causes dyslipidemia in experimental animals. Zinc oxide is the most widely used nanoparticles among various nanomaterials. Zinc oxide nanoparticles were ameliorated hepatotoxicity, hematotoxicity oxidative stress, and disturbance in the antioxidant defense system induced by cyclophosphamide in experimental animals.

Virology

Assessment of community knowledge, attitude and practice on common zoonotic diseases in Jinka town, Southern Ethiopia

A cross-sectional study was conducted from November 2018 to May 2019 in and around Jinka town, to assess the community’s knowledge, attitude, and practice on common zoonotic disease. A total of 330 randomly selected participants had voluntarily filled the semi-structured questionnaire. Accordingly, age, religion, education, occupation and marital status of the respondents were significantly associated with their knowledge on the zoonotic disease

Novel Corona Virus Outbreak in Palestine

The novel corona virus (2019-nCoV, or COVID-19) epidemic started in Bethlehem/Palestine and spread to many Palestinian cities and villages. The numbers of new infections in Palestine are increasing, which have activated all the public health, governance and even private concerns. A series of mandatory actions have been taken by the ministry of health (MOH), governmental and community support. 

Emotional support and diverse treatments: The role of social workers during the COVID-19 pandemic- Hasharon Corona hospital experience

COVID-19 is one of the greatest global health pandemic crises of the 21th century, affecting millions of people worldwide. Neither known treatments nor vaccines currently exist for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a result, the disease is spreading throughout the world causing health and economic consequences

Clinical experience of COVID-19 patients: Disease course and treatment features

The first and only Corona Israeli hospital opened on March 2020 designated to treat positive COVID-19    in-patients solely. We present our clinical experience and outcome on 52 COVID-19 in-patients on Corona B department. The research cohort included 52 COVID-19 adult Israeli patients. Information on epidemiologic, demographic, clinical, laboratory, imaging and treatments features. Research individuals were categorised into disease severity categories of mild versus moderate and severe disease was compared.

Pulmonology

A case of giant hiatal hernia in an elderly patient: When spleen, stomach, duodenum and colon slide into thorax- A rare cause of dyspnea and chest pain

Giant hiatal hernias, generally seen at advanced ages, can rarely cause cardiorespiratory symptoms such as dyspnea and chest pain. Here, we aimed to present a case with a large hiatal hernia that largely protruded to intrathoracic cavity and caused dyspnea, particularly at postprandial period. We report a case of a 74-year-old female who presented with one-month history of progressive shortness of breath and left sided chest pain. 

Immunology

Clinical study of the effects of immutonic capsule on blood immune parameters in human volunteers

Many herbs and natural food materials have been historically recognized as an effective panacea that can establish a balanced inflammatory response and promote healthy immune response as well as have antibacterial and viral effects. The clinical use of some medications can cause serious side effects. We propose that natural ingredients could serve as food supplement immune tonic with antibacterial & antiviral properties that serve as a better prophylactic and therapeutic approach against COVID-19 and others infections.

Cardiology

Post-infarctual left ventricular apical thrombosis successfully treated with low-dose apixaban: A case report

The recommended treatment for ventricular thrombosis is based on vitamin K antagonists use for at least 3 months. Till now there are not completed trials that allow use of direct oral anticoagulants for this specific complication in neither chronic nor acute settings. We report the case of a subacute left ventricular apical thrombosis complicating a myocardial infarction in a 78-years-old patient effectively treated with low-dose apixaban (2.5 mg twice daily) associated with dual antithrombotic therapy. 

Neurology

Case report of a rare condition of thunderclap headache

This is a report to create awareness among clinicians on a very rare condition of thunderclap headache. A 51-year-old lady presented with recurrent thunderclap headaches over the preceding 3 days. This presentation sounds like Subarachnoid haemorrhage initially, but further investigation revealed reversible cerebral vasoconstriction syndrome. In this report, the clinical presentation, investigation and management for Reversible Cerebral Vasoconstriction Syndrome (RCVS) including its outcome are described.

Isolated penile Gas gangrene in spinal cord injury secondary to priapism: A case Report

Priapism as such is rare in spinal cord injury. It can be ischemic or non ischemic Priapism. The ischemic variety is painful and spontaneous while non ischemic is painless making diagnosis delayed. Penile gas gangrene in spinal cord injury is rare, but could be initiated in patients with ischemic Priapism as a triggering factor. Mortatility can be reduced by awaring care givers, general practitioners and paramedical staff about absence of penile pain in Priapism underlying spinal cord injury , which needs early recognition and appropriate management.

Gynecology

Case report of ovarian torsion in the first trimester of pregnancy

Ovarian torsion refers to the complete or partial rotation of the ovary on its ligamentous supports, often resulting in impedance of its blood supply. It is one of the most common gynecologic surgical emergencies and may affect females of all ages. Torsion of the ovary in the pregnancy is very rare and it commonly occurs during the third trimester. It is frequently associated with ovary stimulation in In-vitro-fertilisation (IVF) or Ovary masses.

Current trends in identifying biomarkers in endometrial cancer

Endometrial cancer (EC) is the sixth most common cancer in women and accounts for about 8.2 % of the worldwide incidence of cancer in women. Its incidence varies across regions and is rising as life expectancy increases. Although, there have been significant recent advances in our understanding of endometrial cancer. But there is paucity of a reliable screening test. When diagnosed at an early stage, EC is highly curable and has excellent overall 5 –year survival rates. 

Pharmacy

Different techniques for Analysis of Aspirin, Caffeine, Diclofenac Sodium and Paracetamol: Review Article

Early treatment of pain is of a great importance as unrelieved pain can have profound psychological effects on the patient, and acute pain that is poorly managed initially can degenerate into chronic pain, which may prove to be much more difficult to treat. In this review article, we will shed the light on different ways of some analgesic drugs monitoring and analysis using different techniques in addition to the most recommended combinations of our cited drugs for pain relief.

Biotechnology

Flavonoids from Carica papaya Linn. against SARS-CoV-2 protease: Molecular Docking and ADME analysis

The objective of the study is to investigate the inhibitory activity of selected flavonoids from the plant Carica Papaya Linn. using molecular docking against SARS-CoV-2 or Covid-19. In silico bioinformatics tools was used to investigate the capabilities of flavonoids as an acclamatory inhibitor of Covid-19. The 3D structure of the receptor was retrieved from PDB and of the ligands from PubChem databases. Docking analysis of the selected compounds was performed employing Autodock and PyRx.